Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

Zhang, Wei; Wang, Yang; Kong, Yichun

doi:10.1167/iovs.18-25617

Public

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

Published in Investigative Ophthalmology & Visual Science • Jan 18, 2019

Authors:

Wei Zhang

Yang Wang

Yichun Kong

Abstract

Purpose: In this study, we aim to investigate whether mesenchymal stem cell (MSC)-derived exosomes (MSC-Exos) could regulate hyperglycemia-induced retinal inflammation by transferring microRNA-126 (miR-126). Methods: MSC-Exos were isolated from the media of human umbilical cord-derived mesenchymal s...

Subject

Mesenchymal stem cell

Inflammation

Inflammasome

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