Effect of Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention on Microvascular Obstruction in Patients With Acute Myocardial Infarction

McCartney, Peter; Eteiba, Hany; Maznyczka, Annette; McEntegart, Margaret; P. Greenwood, John; Muir, Douglas; Chowdhary, Saqib; Gershlick, Anthony; Appleby, Clare; Cotton, James; Wragg, Andrew; Curzen, Nick; G. Oldroyd, Keith; Lindsay, Mitchell; Paul Rocchiccioli, J.; Shaukat, Aadil; Good, Richard; Watkins, Stuart; Robertson, Keith; J. Malkin, Christopher; Martin, Lynn; Gillespie, Lynsey; J. Ford, Thomas; C. Petrie, Mark; W. Macfarlane, Peter; C. Tait, Robert; Welsh, Paul; Sattar, Naveed; A.P. Weir, Robin; A.A. Fox, Keith; Ford, Ian; McConnachie, Alex; Berry, Colin; the T-TIME Group, for

doi:10.1001/jama.2018.19802

Public

Effect of Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention on Microvascular Obstruction in Patients With Acute Myocardial Infarction

Published in JAMA • Jan 1, 2019

Authors:

Peter McCartney

Hany Eteiba

Annette Maznyczka

Abstract

Importance: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction (STEMI) and is associated with adverse outcomes. Objective: To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with alteplase infused e...

Subject

Medicine

Myocardial infarction

Percutaneous coronary intervention

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