Secreted amyloid-β precursor protein functions as a GABA <sub>B</sub> R1a ligand to modulate synaptic transmission

C. Rice, Heather; de Malmazet, Daniel; Schreurs, An; Frère, Samuel; Van Molle, Inge; N. Volkov, Alexander; Creemers, Eline; Vertkin, Irena; Nys, Julie; Ranaivoson, F.M.; Comoletti, Davide; N. Savas, Jeffrey; Remaut, Han; Balschun, Detlef; Wierda, Keimpe; Slutsky, Inna; Farrow, Karl; De Strooper, Bart; de Wit, Joris

doi:10.1126/science.aao4827

Public

Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Published in Science • Jan 10, 2019

Authors:

Heather C. Rice

Daniel de Malmazet

An Schreurs

Abstract

A physiological function for sAPP? Although the pathological role of the amyloid-β precursor protein (APP) in Alzheimer's disease is well studied, the physiological role of this protein has remained elusive. Rice et al. found that the secreted ectodomain of APP (sAPP) binds to GABA B R1a, the metabo...

Subject

Neurotransmission

Ectodomain

Neurotransmitter

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