Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Singh, Rajbir; Chandrashekharappa, Sandeep; R. Bodduluri, Sobha; V. Baby, Becca; Hegde, Bindu; G. Kotla, Niranjan; Hiwale, Ankita; Saiyed, Taslimarif; D. Patel, Paresh; Vijay–Kumar, Matam; G. I. Langille, Morgan; M. Douglas, Gavin; Cheng, Xi; C. Rouchka, Eric; Waigel, Sabine; W. Dryden, Gerald; Alatassi, Houda; Zhang, Huang-Ge; Haribabu, Bodduluri; Kumar Vemula, Praveen; R. Jala, Venkatakrishna

doi:10.1038/s41467-018-07859-7

Public

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Published in Nature Communications • Jan 3, 2019

Authors:

Rajbir Singh

Sandeep Chandrashekharappa

Sobha R. Bodduluri

Abstract

The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain elusive. Urolithin A (UroA), a major microbial metabolite derived from polyphenolics of berri...

Subject

Aryl hydrocarbon receptor

Metabolite

Gut flora

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