CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

G. Majzner, Robbie; Theruvath, Johanna; Nellan, Anandani; Heitzeneder, Sabine; Cui, Yongzhi; Mount, Christopher; P. Rietberg, Skyler; H. Linde, Miles; Xu, Peng; Rota, Christopher; Sotillo, Elena; Labanieh, Louai; W. Lee, Daniel; J. Orentas, Rimas; S. Dimitrov, Dimiter; Zhu, Zhongyu; St. Croix, Brad; Delaidelli, Alberto; Sekunova, Alla; Bonvini, Ezio; S. Mitra, Siddhartha; Quezado, Martha; Majeti, Ravindra; Monje, Michelle; H. Sorensen, Poul; M. Maris, John; L. Mackall, Crystal

doi:10.1158/1078-0432.ccr-18-0432

Public

CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

Published in Clinical Cancer Research • Jan 17, 2019

Authors:

Robbie G. Majzner

Johanna Theruvath

Anandani Nellan

Abstract

PURPOSE: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute lymphoblastic leukemia, but this has not yet transl...

Subject

Cancer

Antigen

Medicine

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