X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Song, Juan; Janiszewski, Adrian; De Geest, Natalie; Vanheer, Lotte; Talón, Irene; El Bakkali, Mouna; Oh, Taeho; Pasque, Vincent

doi:10.1016/j.stemcr.2018.12.004

Public

X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Published in Stem Cell Reports • Jan 10, 2019

Authors:

Juan Song

Adrian Janiszewski

Natalie De Geest

Abstract

Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differences in the properties of iPSCs is still unclear. We show tha...

Subject

Induced pluripotent stem cell

Biology

Chromatin

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