Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

W. van der Helm, Marinke; Henry, Olivier; Bein, Amir; Hamkins-Indik, Tiama; J. Cronce, Michael; D. Leineweber, William; Odijk, Mathieu; D. van der Meer, Andries; C. T. Eijkel, Jan; E. Ingber, Donald; van den Berg, Albert; I. Segerink, Loes

doi:10.1039/c8lc00129d

Public

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

Published in Lab on a Chip • Jan 1, 2019

Authors:

Marinke W. van der Helm

Olivier Henry

Amir Bein

Abstract

Here, we describe methods for combining impedance spectroscopy measurements with electrical simulation to reveal transepithelial barrier function and tissue structure of human intestinal epithelium cultured inside an organ-on-chip microfluidic culture device. When performing impedance spectroscopy m...

Subject

Function (biology)

Barrier function

Dielectric spectroscopy

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