Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

di Domenico, Angelique; Carola, Giulia; Calatayud, Carles; Pons‐Espinal, Meritxell; Pablo Muñoz, Juan; Richaud‐Patín, Yvonne; Fernández‐Carasa, Irene; Gut, Marta; Faella, Armida; Parameswaran, Janani; Soriano, Jordi; Ferrer, Isidró; Tolosa, Eduardo; Zorzano, António; María Cuervo, Ana; Raya, Ángel; Consiglio, Antonella

doi:10.1016/j.stemcr.2018.12.011

Public

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

Published in Stem Cell Reports • Jan 10, 2019

Authors:

Angelique di Domenico

Giulia Carola

Carles Calatayud

Abstract

Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous contribution, in particular of astrocytes, during PD pathogenesis has been suggested by observational studies, but remains t...

Subject

Neurodegeneration

Biology

Astrocyte

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!