Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo

Wu, Shengnan; Lu, Qiulun; Ding, Ye; Wu, Yin; Qiu, Yu; Wang, Pei; Mao, Xiaoxiang; Huang, Kai; Xie, Zhonglin; Zou, Ming‐Hui

doi:10.1161/circulationaha.118.033552

Public

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo

Published in Circulation • Jan 16, 2019

Authors:

Shengnan Wu

Qiulun Lu

Ye Ding

Abstract

Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum membranes (MAMs). The roles of Fundc1 and MAMs in diabetic hearts remain unknown. The aims of this study, therefore, were to determine...

Subject

Endoplasmic reticulum

Internal medicine

Endocrinology

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