Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice

Wang, Haidong; Wang, Bin; Zhang, Aiqing; Hassounah, Faten; Seow, Yiqi; J. A. Wood, Matthew; Ma, Fuying; D. Klein, Janet; Russ Price, S.; H. Wang, Xiaonan

doi:10.1016/j.ymthe.2019.01.008

Public

Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice

Published in Molecular Therapy • Jan 18, 2019

Authors:

Haidong Wang

Bin Wang

Aiqing Zhang

Abstract

Our previous study showed that miR-29 attenuates muscle wasting in chronic kidney disease. Other studies found that miR-29 has anti-fibrosis activity. We hypothesized that intramuscular injection of exosome-encapsulated miR-29 would counteract unilateral ureteral obstruction (UUO)-induced muscle was...

Subject

Exosome

Muscle atrophy

Fibrosis

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