Melatonin attenuates TNF‐α and IL‐1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

Huang, Chien‐Chung; Chiou, Chen‐Hsiang; Liu, Shan‐Chi; Hu, Sung‐Lin; Su, Chen‐Ming; Tsai, Chun‐Hao; Tang, Chih‐Hsin

doi:10.1111/jpi.12560

Public

Melatonin attenuates TNF‐α and IL‐1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

Published in Journal of Pineal Research • Jan 16, 2019

Authors:

Chien‐Chung Huang

Chen‐Hsiang Chiou

Shan‐Chi Liu

Abstract

The hormone melatonin has many properties, including antioxidant, anti-inflammatory, and immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several inflammatory autoimmune diseases, but its effects in rheumatoid arthritis (RA) remain controversial. We sought to determine h...

Subject

Melatonin

Protein kinase B

Tumor necrosis factor alpha

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