Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Qin, Xing; Guo, Haiyan; Wang, Xiaoning; Zhu, Xueqin; Yan, Ming; Wang, Xu; Xu, Qin; Shi, Jianbo; Lu, Eryi; Chen, Wantao; Zhang, Jianjun

doi:10.1186/s13059-018-1604-0

Public

Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Published in Genome biology • Jan 14, 2019

Authors:

Xing Qin

Haiyan Guo

Xiaoning Wang

Abstract

BACKGROUND: Cisplatin resistance is a major challenge for advanced head and neck cancer (HNC). Understanding the underlying mechanisms and developing effective strategies against cisplatin resistance are highly desired in the clinic. However, how tumor stroma modulates HNC growth and chemoresistance...

Subject

Microvesicles

Cisplatin

Cancer research

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