Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Y. Xu-Monette, Ziju; Xiao, Min; Au, Qingyan; Padmanabhan, Raghav; Xu, Bing; Hoe, Nicholas; Rodríguez, Sandra; Torres, Raúl; C. Manyam, Ganiraju; Visco, Carlo; Miao, Yi; Tan, Xiaohong; Zhang, Hongwei; Tzankov, Alexandar; Wang, Jing; Dybkær, Karen; Tam, Wayne; You, Hua; Bhagat, Govind; D. Hsi, Eric; Ponzoni, Maurilio; J.M. Ferreri, Andrés; Møller, Michael; Á. Piris, Miguel; Han van Krieken, J.; N. Winter, Jane; R. Westin, Jason; V. Pham, Lan; Jeffrey Medeiros, L.; Z. Rassidakis, George; Li, Yong; J. Freeman, Gordon; H. Young, Ken

doi:10.1158/2326-6066.cir-18-0439

Public

Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Published in Cancer Immunology Research • Feb 11, 2019

Authors:

Ziju Y. Xu-Monette

Min Xiao

Qingyan Au

Abstract

Abstract PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for 13 types of cancers and are being studied in diffuse large B-cell lymphoma (DLBCL), the most common aggressive B-cell lymphoma. However, whether both PD-1 and CTLA-4 checkpoints are active and clinically significant in DLBCL...

Subject

DECIPHER

Immune system

Immune checkpoint

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!