Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

the Alzheimer’s Disease Neuroimaging Initiative, for; Suárez‐Calvet, Marc; Morenas‐Rodríguez, Estrella; Kleinberger, Gernot; Schlepckow, Kai; Ángel Araque Caballero, Miguel; Franzmeier, Nicolai; Capell, Anja; Fellerer, Katrin; Nuscher, Brigitte; Eren, Erden; Levin, Johannes; Deming, Yuetiva; Piccio, Laura; M. Karch, Celeste; Cruchaga, Carlos; M. Shaw, Leslie; Q. Trojanowski, John; W. Weiner, Michael; Ewers, Michael; Haass, Christian

doi:10.1186/s13024-018-0301-5

Public

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Published in Molecular Neurodegeneration • Jan 10, 2019

Authors:

for the Alzheimer’s Disease Neuroimaging Initiative

Marc Suárez‐Calvet

Estrella Morenas‐Rodríguez

Abstract

BACKGROUND: TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). Soluble TREM2 (sTREM2) resulting from shedding of the TREM2 ectodomain can be detected ...

Subject

Neurodegeneration

Neurology

Medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!