Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

Jia, Dongya; Lu, Mingyang; Hwa Jung, Kwang; Hyoung Park, Jun; Yu, Linglin; N. Onuchic, José; Abraham Kaipparettu, Benny; Levine, Herbert

doi:10.1073/pnas.1816391116

Public

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

Published in Proceedings of the National Academy of Sciences • Feb 7, 2019

Authors:

Dongya Jia

Mingyang Lu

Kwang Hwa Jung

Abstract

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis. However, it is still largely unknown how cancer cells orchestrate gene regulation to balance their glycolysis and OXPHOS acti...

Subject

Metabolic pathway

Biology

Gene

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