Molecular basis for pore blockade of human Na <sup>+</sup> channel Na <sub>v</sub> 1.2 by the μ-conotoxin KIIIA

Pan, Xiaojing; Li, Zhangqiang; Huang, Xiaoshuang; Huang, Gaoxingyu; Gao, Shuai; Shen, Huaizong; Liu, Lei; Lei, Jianlin; Yan, Nieng

doi:10.1126/science.aaw2999

Public

Molecular basis for pore blockade of human Na + channel Na v 1.2 by the μ-conotoxin KIIIA

Published in Science • Feb 15, 2019

Authors:

Xiaojing Pan

Zhangqiang Li

Xiaoshuang Huang

Abstract

Targeting sodium channels Voltage-gated sodium (Na v ) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these channels, making it challenging to develop specific therapeutics. A core α subunit is sufficient for voltage sensing and ion conductance, but f...

Subject

Blockade

Conotoxin

Channel (broadcasting)

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