RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

Monaco, Gianni; Lee, Bernett; Xu, Weili; Mustafah, Seri; Yi Hwang, You; Carré, Christophe; Burdin, Nicolas; Visan, Lucian; Ceccarelli, Michele; Poidinger, Michael; Zippelius, Alfred; Pedro de Magalhães, João; Larbi, Anis

doi:10.1016/j.celrep.2019.01.041

Public

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

Published in Cell Reports • Feb 1, 2019

Authors:

Gianni Monaco

Bernett Lee

Weili Xu

Abstract

The molecular characterization of immune subsets is important for designing effective strategies to understand and treat diseases. We characterized 29 immune cell types within the peripheral blood mononuclear cell (PBMC) fraction of healthy donors using RNA-seq (RNA sequencing) and flow cytometry. O...

Subject

Deconvolution

Transcriptome

Immune system

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