Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Højgaard Thybo, Kasper; Hägi‐Pedersen, Daniel; B. Dahl, Jørgen; Wetterslev, Jørn; Nersesjan, Mariam; Christian Jakobsen, Janus; Anker Pedersen, Niels; Overgaard, Søren; M. Schrøder, Henrik; Schmidt, Harald; Gottfrid Bjørck, Jan; Skovmand, Kamilla; Frederiksen, Rune; Buus-Nielsen, Morten; Voss Sørensen, Charlotte; Smedegaard Kruuse, Laura; Lindholm, Peter; Mathiesen, Ole

doi:10.1001/jama.2018.22039

Public

Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Published in JAMA • Feb 12, 2019

Authors:

Kasper Højgaard Thybo

Daniel Hägi‐Pedersen

Jørgen B. Dahl

Abstract

Importance: Multimodal postoperative analgesia is widely used but lacks evidence of benefit. Objective: Investigate beneficial and harmful effects of 4 nonopioid analgesics regimens. Design, Setting, and Participants: Randomized, blinded, placebo-controlled, 4-group trial in 6 Danish hospitals with ...

Subject

Medicine

Acetaminophen

Ibuprofen

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