Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

El Hayek, Lauretta; Khalifeh, Mohamad; Zibara, Victor; Abi Assaad, Rawad; Emmanuel, Nancy; Karnib, Nabil; El-Ghandour, Rim; Nasrallah, Patrick; Bilen, Maria; Ibrahim, Pascale; Younes, Joe; Abou Haidar, Edwina; Barmo, Nour; Jabre, Vanessa; S. Stephan, Joseph; F. Sleiman, Sama

doi:10.1523/jneurosci.1661-18.2019

Public

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

Published in Journal of Neuroscience • Jan 28, 2019

Authors:

Lauretta El Hayek

Mohamad Khalifeh

Victor Zibara

Abstract

Exercise promotes learning and memory formation. These effects depend on increases in hippocampal BDNF, a growth factor associated with cognitive improvement and the alleviation of depression symptoms. Identifying molecules that are produced during exercise and that mediate hippocampal Bdnf expressi...

Subject

Neurotrophic factors

Hippocampal formation

Brain-derived neurotrophic factor

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!