Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer

Gao, Qinglei; Yang, Zongyuan; Xu, Sen; Li, Xiaoting; Yang, Xin; Jin, Ping; Liu, Yi; Zhou, Xiaoshui; Zhang, Taoran; Gong, Cheng; Xiao, Wei; Liu, Dan; Sun, Chaoyang; Chen, Gang; Hu, Junbo; Li, Meng; Zhou, Jianfeng; Sawada, Kenjiro; Fruscio, Robert; W. Grunt, Thomas; Wischhusen, Jörg; Manuel Vargas-Hernández, Víctor; Pothuri, Bhavana; L. Coleman, Robert

doi:10.1084/jem.20180765

Public

Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer

Published in The Journal of Experimental Medicine • Feb 1, 2019

Authors:

Qinglei Gao

Zongyuan Yang

Sen Xu

Abstract

High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal dissemination, which distinguishes it from low-grade serous ovarian cancer (LGSOC). Here, we describe the aggressive nature of HGSOC ascitic tumor cells (ATCs) characterized by integrin α5high (ITGA5high) ATCs, which...

Subject

Ovarian cancer

Stromal cell

Serous fluid

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