Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

Zhao, Jinxuan; Li, Xueling; Hu, Jiaxin; Chen, Fu; Qiao, Shuaihua; Sun, Xuan; Gao, Ling; Xie, Jun; Xu, Biao

doi:10.1093/cvr/cvz040

Public

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

Published in Cardiovascular Research • Feb 7, 2019

Authors:

Jinxuan Zhao

Xueling Li

Jiaxin Hu

Abstract

AIMS: Mesenchymal stromal cells (MSCs) gradually become attractive candidates for cardiac inflammation modulation, yet understanding of the mechanism remains elusive. Strikingly, recent studies indicated that exosomes secreted by MSCs might be a novel mechanism for the beneficial effect of MSCs tran...

Subject

Mesenchymal stem cell

Microvesicles

Macrophage polarization

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