Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Valsesia, Armand; Wang, Qiao‐Ping; Gheldof, Nele; Carayol, Jérôme; Ruffieux, Hélène; Clark, Teleri; Shenton, Victoria; J. Oyston, Lisa; Lefebvre, Grégory; Métairon, Sylviane; Chabert, Christian; Walter, Ondine; Mironova, Polina; Lau, Paulina; Descombes, Patrick; Viguerie, Nathalie; Langin, Dominique; Harper, Mary‐Ellen; Astrup, Arne; H. M. Saris, Wim; Dent, Robert; Gregory Neely, G.; Hager, Jörg

doi:10.1038/s41467-019-08492-8

Public

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Published in Nature Communications • Feb 1, 2019

Authors:

Armand Valsesia

Qiao‐Ping Wang

Nele Gheldof

Abstract

Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-...

Subject

Genome-wide association study

Biology

Genetic association

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