Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

S. Dashti, Hassan; E. Jones, Samuel; R. Wood, Andrew; M. Lane, Jacqueline; T. van Hees, Vincent; Wang, Heming; A. Rhodes, Jessica; Song, Yanwei; Patel, Krunal; Anderson, Simon; N. Beaumont, Robin; A. Bechtold, David; Bowden, Jack; E. Cade, Brian; Garaulet, Marta; D. Kyle, Simon; A. Little, Max; Loudon, Andrew; I. Luik, Annemarie; A. J. L. Scheer, Frank; Spiegelhalder, Kai; Tyrrell, Jessica; J. Gottlieb, Daniel; Tiemeier, Henning; Ray, David; Purcell, Shaun; M. Frayling, Timothy; Redline, Susan; A. Lawlor, Debbie; K. Rutter, Martin; N. Weedon, Michael; Saxena, Richa

doi:10.1038/s41467-019-08917-4

Public

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Published in Nature Communications • Mar 7, 2019

Authors:

Hassan S. Dashti

Samuel E. Jones

Andrew R. Wood

Abstract

Abstract Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration ...

Subject

Genome-wide association study

Mendelian randomization

Biology

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