Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Chen, Yunzhao; Wang, Dandan; Peng, Hao; Chen, Xi; Han, Xueping; Yu, Jie; Wang, Wenjie; Liang, Lirong; Liu, Zheng; Zheng, Yi; Hu, Jianming; Yang, Lan; Li, Jun; Zhou, Hong; Cui, Xiaobin; Li, Feng

doi:10.1186/s12943-018-0930-x

Public

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Published in Molecular Cancer • Jan 4, 2019

Authors:

Yunzhao Chen

Dandan Wang

Hao Peng

Abstract

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat org...

Subject

Angiogenesis

Cancer research

Biology

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