Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.

AE, Whitton; AI, Green; DA, Pizzagalli; RM, Roth; JM, Williams; MF, Brunette

doi:10.1093/schbul/sby185

Public

Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.

Shared by NobleBlocks on Oct 1, 2019 • 12:00 AM UTC

Authors:

Whitton AE

Green AI

Pizzagalli DA

Abstract

Antipsychotics that are potent dopamine (DA) D2 receptor antagonists have been linked to elevated levels of nicotine dependence in smokers with schizophrenia. Because activation of D2 receptors mediates motivation for nicotine, we examined whether potent D2 antagonists would diminish nicotine's abil...

Subject

Nicotine Dependence

Antipsychotics

Reward Learning

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