Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Pan, Yong; Hui, Xiaoyan; L.C. Hoo, Ruby; Ye, Dewei; Yuk Cheung Chan, Cyrus; Feng, Tianshi; Wang, Yu; Siu Ling Lam, Karen; Xu, Aimin

doi:10.1172/jci123069

Public

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Published in Journal of Clinical Investigation • Jan 21, 2019

Authors:

Yong Pan

Xiaoyan Hui

Ruby L.C. Hoo

Abstract

Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain elusive. Here we identified adipocyte-secreted mi...

Subject

Adipose tissue

Adipocyte

Inflammation

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