Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing <scp>NLRP</scp>3 inflammasomes and <scp>TLR</scp>4/<scp>NF</scp>‐κB signaling pathway

Jin, Xin; Liu, Ming‐Yan; Zhang, Dongfang; Zhong, Xin; Du, Ke; Qian, Ping; Yao, Weifan; Gao, Hua; Wei, Minjie

doi:10.1111/cns.13086

Public

Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway

Published in CNS Neuroscience & Therapeutics • Jan 24, 2019

Authors:

Xin Jin

Ming‐Yan Liu

Dongfang Zhang

Abstract

AIMS: Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti-inflammation and neuroprotective properties; however, its effects during Alzheimer's disease (AD) treatment have not been well studied. This study aimed to in...

Subject

Neuroinflammation

Microglia

Proinflammatory cytokine

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