Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

E. Jones, Samuel; M. Lane, Jacqueline; R. Wood, Andrew; T. van Hees, Vincent; Tyrrell, Jessica; N. Beaumont, Robin; R. Jeffries, Aaron; S. Dashti, Hassan; Hillsdon, Melvyn; S. Ruth, Katherine; A. Tuke, Marcus; Yaghootkar, Hanieh; A. Sharp, Seth; Jie, Yingjie; Thompson, William; Harrison, Jamie; Dawes, Amy; M. Byrne, Enda; Tiemeier, Henning; V. Allebrandt, Karla; Bowden, Jack; Ray, David; M. Freathy, Rachel; Murray, Anna; R. Mazzotti, Diego; Gehrman, Philip; A. Lawlor, Debbie; M. Frayling, Timothy; K. Rutter, Martin; A. Hinds, David; Saxena, Richa; N. Weedon, Michael

doi:10.1038/s41467-018-08259-7

Public

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Published in Nature Communications • Jan 29, 2019

Authors:

Samuel E. Jones

Jacqueline M. Lane

Andrew R. Wood

Abstract

Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with a...

Subject

Chronotype

Circadian rhythm

Genome-wide association study

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