Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

Cui, Bai; Luo, Yuanyuan; Tian, Pengfei; Peng, Fei; Lü, Jinxin; Yang, Yongliang; Su, Qitong; Liu, Bing; Yu, Jiachuan; Luo, Xudong; Liu, Yin; Cheng, Wei; An, Fan; He, Bin; Liang, Dapeng; Wu, Sijin; Chu, Peng; Song, Luyao; Liu, Xinyu; Luo, Huandong; Xu, Jie; Pan, Yujia; Wang, Yang; Li, Dangsheng; Huang, Peng; Yang, Qingkai; Zhang, Lingqiang; P. Zhou, Binhua; Liu, Suling; Xu, Guowang; W.‐F. Lam, Eric; W. Kelley, Keith; Liu, Quentin

doi:10.1172/jci121685

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Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

Published in Journal of Clinical Investigation • Jan 27, 2019

Authors:

Bai Cui

Yuanyuan Luo

Pengfei Tian

Abstract

Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring....

Subject

Lactate dehydrogenase A

Lactate dehydrogenase

Breast cancer

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