Oral versus Intravenous Antibiotics for Bone and Joint Infection

Kwong Li, Ho; Rombach, Ines; Zambellas, Rhea; Sarah Walker, A.; McNally, Martin; L. Atkins, Bridget; A. Lipsky, Benjamin; Hughes, Harriet; Bose, Deepa; Kümin, Michelle; Scarborough, Claire; C. Matthews, Philippa; Brent, Andrew; Manuel Lomas, José; Gundle, Roger; Rogers, M.; Taylor, Adrian; Angus, Brian; Byren, Ivor; R. Berendt, Anthony; Warren, Simon; E. Fitzgerald, Fiona; Mack, Damien; Hopkins, Susan; Folb, Jonathan; Reynolds, Helen; Moore, Elinor; R. Marshall, Jocelyn; Jenkins, Neil; E. Moran, Christopher; Woodhouse, Andrew; Stafford, Samantha; Seaton, R.A.; Vallance, Claire; Hemsley, Carolyn; Bisnauthsing, Karen; Sandoe, Jonathan; Aggarwal, Ila; Ellis, Simon; Bunn, Deborah; Sutherland, Rebecca; Barlow, Gavin; Cooper, Cushla; Geue, Claudia; McMeekin, Nicola; Briggs, Andrew; Sendi, Parham; Khatamzas, Elham; Wangrangsimakul, Tri; Nicholas Wong, T.H.; Barrett, Lucinda; Alvand, Abtin; Old, ChristopherW.; Bostock, Jennifer; R. Paul, John; Cooke, Graham; Thwaites, Guy; Bejon, Philip; Scarborough, Matthew

doi:10.1056/nejmoa1710926

Public

Oral versus Intravenous Antibiotics for Bone and Joint Infection

Published in New England Journal of Medicine • Jan 30, 2019

Authors:

Ho Kwong Li

Ines Rombach

Rhea Zambellas

Abstract

BACKGROUND: The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS: We enrolled adults who were being treated f...

Subject

Antibiotics

Medicine

Intravenous therapy

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