Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics

Gandhi, Jason; C. Antonelli, Anthony; Afridi, Adil; Vatsia, Sohrab; Joshi, Gunjan; Romanov, Victor; Murray, Ian; Ali Khan, Sardar

doi:10.1515/revneuro-2016-0035

Public

Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics

Published in Reviews in the Neurosciences • Feb 11, 2019

Authors:

Jason Gandhi

Anthony C. Antonelli

Adil Afridi

Abstract

Protein folding is a complex, multisystem process characterized by heavy molecular and cellular footprints. Chaperone machinery enables proper protein folding and stable conformation. Other pathways concomitant with the protein folding process include transcription, translation, post-translational m...

Subject

Proteostasis

Protein aggregation

Protein folding

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!