Selectivity of Guanine Nucleotide Exchange Factor-mediated Cdc42 activation in primary human endothelial cells

R. Reinhard, Nathalie; van der Niet, Sanne; O. Chertkova, Anna; Postma, Marten; L. Hordijk, Peter; W. J. Gadella, Theodorus; Goedhart, Joachim

doi:10.1101/541219

Public

Selectivity of Guanine Nucleotide Exchange Factor-mediated Cdc42 activation in primary human endothelial cells

Published in bioRxiv (Cold Spring Harbor Laboratory) • Feb 5, 2019

Authors:

Nathalie R. Reinhard

Sanne van der Niet

Anna O. Chertkova

Abstract

Abstract The Rho GTPase family is involved in actin dynamics and regulates the barrier function of the endothelium. One of the main barrier-promoting Rho GTPases is Cdc42, also known as cell division control protein 42 homolog. Currently, regulation of Cdc42-based signaling networks in endothelial c...

Subject

Guanine nucleotide exchange factor

CDC42

Pleckstrin homology domain

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