The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

Gentili, Matteo; Lahaye, Xavier; Nadalin, Francesca; Nader, G.; Puig Lombardi, Emilia; Hervé, Solène; S. De Silva, Nilushi; C. Rookhuizen, Derek; Zueva, Elina; Goudot, Christel; Maurin, Mathieu; Bochnakian, Aurore; Amigorena, Sebastián; Piel, Matthieu; Fachinetti, Daniele; Londoño‐Vallejo, Arturo; Manel, Nicolas

doi:10.1016/j.celrep.2019.01.105

Public

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

Published in Cell Reports • Feb 1, 2019

Authors:

Matteo Gentili

Xavier Lahaye

Francesca Nadalin

Abstract

Cytosolic DNA activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS), an innate immune sensor pivotal in anti-microbial defense, senescence, auto-immunity, and cancer. cGAS is considered to be a sequence-independent DNA sensor with limited access to nuclear DNA beca...

Subject

Innate immune system

Cell biology

Nuclear localization sequence

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