Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

Liu, Li; Wei, Qiang; Lin, Qingqing; Fang, Jun; Wang, Haibo; Kwok, Hauyee; Tang, Hangying; Nishiura, Kenji; Peng, Jie; Tan, Zhiwu; Wu, Tongjin; Cheung, Ka‐Wai; Chan, Kwok‐Hung; Álvarez, Xavier; Qin, Chuan; A. Lackner, Andrew; Perlman, Stanley; Yuen, Kwok‐Yung; Chen, Zhiwei

doi:10.1172/jci.insight.123158

Public

Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

Published in JCI Insight • Feb 20, 2019

Authors:

Li Liu

Qiang Wei

Qingqing Lin

Abstract

Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. In SARS-CoV/mac...

Subject

Proinflammatory cytokine

Medicine

Immunology

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