Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation

Wang, Zhenzhen; Tong, Dongdong; Han, Cong; Zhao, Zhenghao; Wang, Xiaofei; Jiang, Ting; Li, Qian; Liu, Siyuan; Chen, Lin; Chen, Yanke; Li, Ang; Huang, Chen

doi:10.1016/j.ebiom.2018.12.061

Public

Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation

Published in EBioMedicine • Feb 20, 2019

Authors:

Zhenzhen Wang

Dongdong Tong

Cong Han

Abstract

BACKGROUND: The cross-talk between RNA binding proteins (RBPs) and microRNAs (miRNAs) in the regulation of gene expression is a complex process. Here, we describe a new mode of regulation of TRIM25 expression mediated by an antagonistic interplay between IGF2BP3 and miR-3614-3p. METHODS: The express...

Subject

Downregulation and upregulation

microRNA

Cancer research

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