Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor–Positive Metastatic Breast Cancer

C. Turner, Nicholas; Liu, Yuan; Zhu, Zhou; Loi, Sherene; Colleoni, Marco; Loibl, Sibylle; DeMichele, Angela; Harbeck, Nadia; André, Fabrice; Amine Bayar, Mohamed; Michiels, Stefan; Zhang, Zhe; Giorgetti, C.; Arnedos, Mónica; Huang Bartlett, Cynthia; Cristofanilli, Massimo

doi:10.1200/jco.18.00925

Public

Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor–Positive Metastatic Breast Cancer

Published in Journal of Clinical Oncology • Feb 26, 2019

Authors:

Nicholas C. Turner

Yuan Liu

Zhou Zhu

Abstract

PURPOSE A large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to fulvestrant. METHODS The PALOMA-3 (ClinicalTrials.gov identifier: NCT01942135 ) trial randomly assigned 521 endocrine-pretreated patients with metastatic bre...

Subject

Palbociclib

Medicine

Fulvestrant

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