Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus

Parks, Tom; S. Elliott, Katherine; Lamagni, Theresa; Auckland, Kathryn; J. Mentzer, Alexander; Guy, Rebecca; Cartledge, Doreen; Strakova, Lenka; O’Connor, Daniel; J. Pollard, Andrew; Neville, Matthew; Mahajan, Anubha; Ashrafian, Houman; Jonathan Chapman, S.; V. S. Hill, Adrian; Sriskandan, Shiranee; C. Knight, Julian

doi:10.1101/559161

Public

Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus

Published in bioRxiv (Cold Spring Harbor Laboratory) • Feb 24, 2019

Authors:

Tom Parks

Katherine S. Elliott

Theresa Lamagni

Abstract

Abstract Invasive group A streptococcal (GAS) disease is uncommon but carries a high case-fatality rate relative to other infectious diseases. Given the ubiquity of mild GAS infections, it remains unclear why healthy individuals will occasionally develop life-threatening infections, raising the poss...

Subject

Human leukocyte antigen

Allele

Odds ratio

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