Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

M. Fischer, Grant; Jalali, Ali; A. Kircher, David; Lee, Won‐Chul; L. McQuade, Jennifer; E. Haydu, Lauren; Y. Joon, Aron; Reuben, Alexandre; Petaccia de Macêdo, Mariana; C. L. Carapeto, Fernando; Yang, Chendong; Srivastava, Anuj; R. Ambati, Chandrashekar; Sreekumar, Arun; W. Hudgens, Courtney; Knighton, Barbara; Deng, Wanleng; D. Ferguson, Sherise; A. Tawbi, Hussein; C. Glitza, Isabella; E. Gershenwald, Jeffrey; Vashisht Gopal, Y.N.; Hwu, Patrick; T. Huse, Jason; A. Wargo, Jennifer; Andrew Futreal, P.; Putluri, Nagireddy; J. Lazar, Alexander; J. DeBerardinis, Ralph; R. Marszalek, Joseph; Zhang, Jianjun; L. Holmen, Sheri; T. Tetzlaff, Michael; A. Davies, Michael

doi:10.1158/2159-8290.cd-18-1489

Public

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

Published in Cancer Discovery • Feb 20, 2019

Authors:

Grant M. Fischer

Ali Jalali

David A. Kircher

Abstract

Abstract There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also underwent whole-exome sequencing, T-cell rec...

Subject

Profiling (computer programming)

Immune system

Melanoma

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