Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

Kim, Jonghoon; Young Kim, Han; Young Song, Seuk; Go, Seok-hyeong; Su Sohn, Hee; Baik, Seungmin; Soh, Min; Kim, Kang; Kim, Dokyoon; Kim, Hyo‐Cheol; Lee, Nohyun; Kim, Byung‐Soo; Hyeon, Taeghwan

doi:10.1021/acsnano.8b08785

Public

Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

Published in ACS Nano • Mar 4, 2019

Authors:

Jonghoon Kim

Han Young Kim

Seuk Young Song

Abstract

Poor O 2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1α) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation. Synovial inflammation in RA can be resolv...

Subject

Reactive oxygen species

Inflammation

Chemistry

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!