Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

Kim, Jonghoon; Young Kim, Han; Young Song, Seuk; Go, Seok-hyeong; Su Sohn, Hee; Baik, Seungmin; Soh, Min; Kim, Kang; Kim, Dokyoon; Kim, Hyo‐Cheol; Lee, Nohyun; Kim, Byung‐Soo; Hyeon, Taeghwan

doi:10.1021/acsnano.8b08785

Public

Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

Published in ACS Nano • Mar 4, 2019

Authors:

Jonghoon Kim

Han Young Kim

Seuk Young Song

Abstract

Poor O2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1α) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation. Synovial inflammation in RA can be resolve...

Subject

Reactive oxygen species

Inflammation

Chemistry

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