Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

Cano, Amanda; Ettcheto, Miren; Chang, Jui-Hsien; Barroso, Emma; Espina, Marta; Anna Kühne, Britta; Barenys, Marta; Auladell, Carmen; Folch, Jaume; B. Souto, Eliana; Camins, Antoni; Turowski, Patric; L. García, María

doi:10.1016/j.jconrel.2019.03.010

Public

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

Published in Journal of Controlled Release • Mar 12, 2019

Authors:

Amanda Cano

Miren Ettcheto

Jui-Hsien Chang

Abstract

Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that EGCG displayed increased stability when formulated as dual-drug loaded PEGylated PLGA nanoparticles (EGCG/AA NPs). Oral admi...

Subject

Epigallocatechin gallate

Chemistry

Pharmacology

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