Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Chakarov, Svetoslav; Ying Lim, Hwee; Tan, Leonard; Yng Lim, Sheau; See, Peter; Lum, Josephine; Zhang, Xiaomeng; Foo, Shihui; Nakamizo, Satoshi; Duan, Kaibo; Ting Kong, Wan; Gentek, Rebecca; Balachander, Akhila; Carbajo, Daniel; Blériot, Camille; Malleret, Benoît; Kit Chung Tam, John; Baig, Sonia; Shabeer, Muhammad; Toh, Sue‐Anne; Schlitzer, Andreas; Larbi, Anis; Marichal, Thomas; MALISSEN, Bernard; Chen, Jinmiao; Poidinger, Michael; Kabashima, Kenji; Bajénoff, Marc; Guan Ng, Lai; Angeli, Véronique; Ginhoux, Florent

doi:10.1126/science.aau0964

Public

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Published in Science • Mar 14, 2019

Authors:

Svetoslav Chakarov

Hwee Ying Lim

Leonard Tan

Abstract

Tissue macrophages have a split personality Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapp...

Subject

Macrophage

Biology

Ecological niche

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