Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury

A. Alexander, Kylie; Tseng, Hsu‐Wen; Fleming, Whitney; Jose, Beulah; Salga, Marjorie; Kulina, Irina; Millard, Susan; R. Pettit, Allison; Genêt, François; Lévesque, Jean-Pierre

doi:10.3389/fimmu.2019.00377

Public

Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury

Published in Frontiers in Immunology • Mar 7, 2019

Authors:

Kylie A. Alexander

Hsu‐Wen Tseng

Whitney Fleming

Abstract

Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of traumatic brain and spinal cord injuries (SCI) which manifest as abnormal bone tissue formation periarticular muscles. NHO are debilitating as they cause pain, partial or total joint ankylosis and vascular and nerve ...

Subject

Oncostatin M

Glycoprotein 130

Cancer research

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