METTL3 and ALKBH5 oppositely regulate m 6 A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Song, Huiwen; Feng, Xing; Zhang, Heng; Luo, Yun; Huang, Juan; Lin, Meihua; Jin, Junfei; Ding, Xue; Wu, Shu-Jing; Huang, He; Yu, Tian; Zhang, Mukun; Hong, Haiou; Yao, Shihua; Zhao, Yongxiang; Zhang, Zhiyong

doi:10.1080/15548627.2019.1586246

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METTL3 and ALKBH5 oppositely regulate m 6 A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Published in Autophagy • Mar 17, 2019

Authors:

Huiwen Song

Xing Feng

Heng Zhang

Abstract

N6-methyladenosine (m6A) mRNA modifications play critical roles in various biological processes. However, no study addresses the role of m6A in macroautophagy/autophagy. Here, we show that m6A modifications are increased in H/R-treated cardiomyocytes and ischemia/reperfusion (I/R)-treated mice heart...

Subject

Biology

TFEB

Hypoxia (environmental)

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