METTL3 and ALKBH5 oppositely regulate m<sup>6</sup>A modification of <i>TFEB</i> mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Song, Huiwen; Feng, Xing; Zhang, Heng; Luo, Yun; Huang, Juan; Lin, Meihua; Jin, Junfei; Ding, Xue; Wu, Shu-Jing; Huang, He; Yu, Tian; Zhang, Mukun; Hong, Haiou; Yao, Shihua; Zhao, Yongxiang; Zhang, Zhiyong

doi:10.1080/15548627.2019.1586246

Public

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Published in Autophagy • Mar 17, 2019

Authors:

Huiwen Song

Xing Feng

Heng Zhang

Abstract

-methyladenosine; MEFs, mouse embryo fibroblasts; Mer, mutated estrogen receptor domains; METTL3, methyltransferase like 3; METTL14, methyltransferase like 14; mRFP, monomeric red fluorescent protein; MTORC1, mechanistic target of rapamycin kinase complex 1; NMVCs, neonatal mouse ventricular cardiom...

Subject

Biology

TFEB

Hypoxia (environmental)

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