Deciphering the complex role of thrombospondin-1 in glioblastoma development

Daubon, Thomas; Léon, Céline; Clarke, Kim; Andrique, Lætitia; Salabert, Laura; Darbo, Élodie; Pineau, Raphaël; Guérit, Sylvaine; Maître, Marlène; Dedieu, Stéphane; Jeanne, Albin; Bailly, Sabine; Feige, Jean‐Jacques; Miletić, Hrvoje; Rossi, Marco; Bello, Lorenzo; Falciani, Francesco; Bjerkvig, Rolf; Bikfalvi, Andréas

doi:10.1038/s41467-019-08480-y

Public

Deciphering the complex role of thrombospondin-1 in glioblastoma development

Published in Nature Communications • Mar 8, 2019

Authors:

Thomas Daubon

Céline Léon

Kim Clarke

Abstract

We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased with glioma grades. Mechanistically, we show that the TGFβ canonical pathway t...

Subject

Matricellular protein

Thrombospondin 1

Gene silencing

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