Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination

Dobaño, Carlota; Santano, Rebeca; Vidal, Marta; Jiménez, Alfons; Jairoce, Chenjerai; Ubillos, Itziar; Dosoo, David; Aguilar, Ruth; Aba Williams, Nana; Díez‐Padrisa, Núria; Ayestaran, Aintzane; Valim, Clarissa; Poku Asante, Kwaku; Owusu‐Agyei, Seth; E. Lanar, David; S. Chauhan, Virander; E. Chitnis, Chetan; Dutta, Sheetij; Angov, Evelina; Gamain, Benoît; L. Coppel, Ross; G. Beeson, James; Reiling, Linda; Gaur, Deepak; Cavanagh, D.; Gyan, Ben; Nhabomba, Augusto; J. Campo, Joseph; Moncunill, Gemma

doi:10.3389/fimmu.2019.00439

Public

Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination

Published in Frontiers in Immunology • Mar 15, 2019

Authors:

Carlota Dobaño

Rebeca Santano

Marta Vidal

Abstract

Naturally acquired immunity (NAI) to Plasmodium falciparum malaria is mainly mediated by IgG antibodies but the subclasses, epitope targets and effector functions have not been unequivocally defined. Dissecting the type and specificity of antibody responses mediating NAI is a key step towards develo...

Subject

Subclass

Malaria

Plasmodium falciparum

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