Prevention of HIV-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in HIV-1-Infected Women With High CD4 Cell Count (IMPAACT PROMISE): A Randomized, Open-Label, Clinical Trial

M. Flynn, Patricia; E. Taha, Taha; Cababasay, Mae; Glenn Fowler, Mary; Mofenson, Lynne; Owor, Maxensia; A. Fiscus, Susan; Stranix‐Chibanda, Lynda; Coutsoudis, Anna; Gnanashanmugam, Devasena; Chakhtoura, Nahida; McCarthy, Katie; Mukuzunga, Cornelius; Makanani, Bonus; Moodley, Dhayendre; Nematadzira, Teacler; Kusakara, Bangini; Patil, Sandesh; Vhembo, Tichaona; Bobat, Raziya; T. Mmbaga, Blandina; Masenya, Maysseb; Nyati, Mandisa; Theron, Gerhard; B. Mulenga, Helen; Butler, Kevin; E. Shapiro, David; PROMISE Study Team, the

doi:10.1097/qai.0000000000001612

Public

Prevention of HIV-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in HIV-1-Infected Women With High CD4 Cell Count (IMPAACT PROMISE): A Randomized, Open-Label, Clinical Trial

Published in JAIDS Journal of Acquired Immune Deficiency Syndromes • Dec 12, 2017

Authors:

Patricia M. Flynn

Taha E. Taha

Mae Cababasay

Abstract

BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in Sub-Saharan Africa and India....

Subject

Breastfeeding

Medicine

Nevirapine

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