Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

Capasso, Anna; Lang, Julie; M. Pitts, Todd; R. Jordan, Kimberly; H. Lieu, Christopher; Lindsey Davis, S.; R. Diamond, Jennifer; Kopetz, Scott; Barbee, Jacob; N. Peterson, Jacob; M. Freed, Brian; W. Yacob, Betelehem; M. Bagby, Stacey; A. Messersmith, Wells; E. Slansky, Jill; Pelanda, Roberta; Gail Eckhardt, S.

doi:10.1186/s40425-019-0518-z

Public

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

Published in Journal for ImmunoTherapy of Cancer • Feb 8, 2019

Authors:

Anna Capasso

Julie Lang

Todd M. Pitts

Abstract

Background The success of agents that reverse T-cell inhibitory signals, such as anti-PD-1/PD-L1 therapies, has reinvigorated cancer immunotherapy research. However, since only a minority of patients respond to single-agent therapies, methods to test the potential anti-tumor activity of rational com...

Subject

Humanized mouse

Medicine

Immune system

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