Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

Ren, Weihua; Hou, Jianfeng; Yang, Chenguang; Wang, Hanjun; Wu, Shuangting; Wu, Yabin; Zhao, Xingpeng; Lü, Chao

doi:10.1186/s13046-019-1027-0

Public

Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

Published in Journal of Experimental & Clinical Cancer Research • Feb 8, 2019

Authors:

Weihua Ren

Jianfeng Hou

Chenguang Yang

Abstract

OBJECTIVE: To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV). METHODS: EV were isolated from culture media of human bone marrow-derived MSCs that were pre-challenged with or without hypoxia (referred to as H-EV and N-EV, respectively...

Subject

Extracellular vesicles

Mesenchymal stem cell

Cell biology

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