Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells

Liang, Lijun; Hui, Kaiyuan; Hu, Chenxi; Wen, Yixuan; Yang, Shikun; Zhu, Panrong; Wang, Lei; Xia, Youyou; Qiao, Yun; Sun, Wen; Fei, Jiayan; Chen, Ting; Zhao, Fenghua; Yang, Baocheng; Jiang, Xiaodong

doi:10.1186/s13046-019-1093-3

Public

Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells

Published in Journal of Experimental & Clinical Cancer Research • Feb 12, 2019

Authors:

Lijun Liang

Kaiyuan Hui

Chenxi Hu

Abstract

BACKGROUND: The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by anlotinib were not fully elucidated, and the underlying mechanisms rela...

Subject

Autophagy

Apoptosis

Viability assay

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