Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea

Rosenstock, Julio; Allison, Dale; L. Birkenfeld, Andreas; Marie Blicher, Thalia; Deenadayalan, Srikanth; Jacobsen, Jacob; Sérusclat, Pierre; Violante, Rafael; Watada, Hirotaka; J. Davies, Melanie; 3 Investigators, PIONEER

doi:10.1001/jama.2019.2942

Public

Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea

Published in JAMA • Mar 23, 2019

Authors:

Julio Rosenstock

Dale Allison

Andreas L. Birkenfeld

Abstract

Importance: Phase 3 trials have not compared oral semaglutide, a glucagon-like peptide 1 receptor agonist, with other classes of glucose-lowering therapy. Objective: To compare efficacy and assess long-term adverse event profiles of once-daily oral semaglutide vs sitagliptin, 100 mg added on to metf...

Subject

Semaglutide

Medicine

Sitagliptin

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